Bromoacetyl chloride → N-[2-(2,6-Dimethoxy-4-methylbenzoyl)phenyl]-N-methylbromoacetamide

HRID 482466ノート

反応式

HRID 482466 の反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][C:14]([CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])=[O:10].[Br:22][CH2:23][C:24](Cl)=[O:25]>ClCCl.O>[CH3:21][O:20][C:12]1[CH:13]=[C:14]([CH3:19])[CH:15]=[C:16]([O:17][CH3:18])[C:11]=1[C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[N:2]([CH3:1])[C:24](=[O:25])[CH2:23][Br:22])=[O:10]

参加物

5

反応物 2

HCID 89602Bromoacetyl chlorideHCID 57322216(2,6-Dimethoxy-4-methylphenyl)(2-methylaminophenyl) Ketone

生成物 1

HCID 19062972N-[2-(2,6-Dimethoxy-4-methylbenzoyl)phenyl]-N-methylbromoacetamide収率 99%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-10 °C

実験手順

To a mixture of 10 g of (2,6-dimethoxy-4-methylphenyl) (2-methylaminophenyl) ketone in 100 ml of dichloromethane and 20 ml of water, cooled to -10° C., are added dropwise 6.34 g of bromoacetyl chloride in 20 dichloromethane. The reaction mixture is allowed to return to room temperature and is then stirred vigorously for 2 hours. The phases are separated after settling has taken place and the organic phase is successively washed with water, dried over sodium sulphate and evaporated to dryness to give beige crystals melting at 121° C.; Yield=99%.

後処理

  1. customto return to room temperature
  2. customThe phases are separated after settling
  3. washthe organic phase is successively washed with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-c793407ad3f74156a2da645ff92600ec
出典データセット
uspto-grants-1998_08
特許番号
US05798353

反応ノート

読み込み中…