Potassium Iodide → HCID 19063054、化合物

HRID 482509ノート

反応式

HRID 482509 の反応式
[C:1]12([C:11]3[CH:12]=[C:13]([C:18]#[C:19][C:20]4[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=4)[CH:14]=[CH:15][C:16]=3[OH:17])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.Br[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][OH:37].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(=O)CC>[C:1]12([C:11]3[CH:12]=[C:13]([C:18]#[C:19][C:20]4[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=4)[CH:14]=[CH:15][C:16]=3[O:17][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][OH:37])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 779706-Bromo-1-hexanolHCID 19063002Methyl 4-[3-(1-adamantyl)-4-hydroxyphenylethynyl]benzoate

生成物 1

HCID 19063054HCID 19063054、化合物

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

2 g (5.1 mmol) of methyl 4-[3-(1-adamantyl)-4-hydroxyphenylethynyl]benzoate, 1.1 ml (8.3 mmol) of 6-bromo-1-hexanol, 1.2 g (8.8 mmol) of potassium carbonate, 20 mg of potassium iodide and 100 ml of 2-butanone were introduced into a round-bottomed flask. The reaction mixture was heated at reflux for twelve hours and was evaporated to dryness, the residue was taken up in water and ethyl acetate and the organic phase was separated by settling, dried over magnesium sulfate and evaporated.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for twelve hours
  3. customwas evaporated to dryness
  4. customethyl acetate and the organic phase was separated
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-8e979760d5ce490b8ea450be9f2e774b
出典データセット
uspto-grants-1998_08
特許番号
US05798354

反応ノート

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