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Ethyl chloroformate → HCID 178526847、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 2-Bromo-5-nitrothiazole | HCID 18211 | — |
| 反応物 | 3-Amino-1-(2-(trifluoromethyl)phenyl)thiourea | HCID 723187 | — |
| 反応物 | 2-(Trifluoromethyl)phenyl isothiocyanate | HCID 737162 | — |
| 反応物 | HCID 178518949 | HCID 178518949 | — |
| 生成物 | HCID 178526847 | HCID 178526847 | 25.8% |
反応手順
The title compound was prepared in a manner similar to that described in Example 5 starting with 2-(trifluoromethyl) phenyl isothiocyanate. The intermediate 4-[2-(trifluoromethyl)phenyl]-3-thiosemicarbazide (2.04 g) was treated with ethyl chloroformate (1.09 g) as in example 5. The reaction product 3-hydroxy-5-mercapto-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole (0.78 g) was reacted with 0.63 g of 2-bromo-5-nitrothiazole as in Example 5. Crystallization from ethanol and water gave 0.3 g of 3-hydroxy-5-[(5-nitrothiazol-2-yl)mercapto]-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole, a yellow solid, MP 183°-185° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05798374 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-89a99e69631c46bba55db86b738d02c9 |
| 出典メモ | uspto-grants-1998_08 |