Dimethylamine → HCID 429128、化合物
反応式
[CH3:1][NH:2][CH3:3].Br[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=[O:7]>C(Cl)Cl>[CH3:1][N:2]([CH3:3])[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=[O:7]参加物
4
反応条件
- 温度
- 20 °C
実験手順
To 66 g (1460 mmole) of anhydrous dimethylamine in 200 ml of methylene chloride and cooled to -30° C. was added a solution of 155 g (664 mmole) of 2-bromo-4'-chloroacetophenone in 200 ml of methylene chloride. After the addition was complete the reaction was allowed to warm to 20° C. Concentration in vacuo, partitioning between diethyl ether and 1M aqueous sodium hydroxide, washing with brine, drying over anhydrous magnesium sulfate, and reconcentration in vacuo gives 130 g of the title compound, an oil.
後処理
- additionAfter the addition
- concentrationConcentration in vacuo
- custompartitioning between diethyl ether and 1M aqueous sodium hydroxide
- washwashing with brine
- dry with materialdrying over anhydrous magnesium sulfate, and reconcentration in vacuo
出典と根拠
- ORDレコード
- ord-172186e2915047bcb86b9570439c7da8
- 出典データセット
- uspto-grants-1998_08
- 特許番号
- US05798311
反応ノート
読み込み中…