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Catechol → 2,3-Dihydro-2,2-dimethyl-7-benzofuranol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Catechol | HCID 289 | — |
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | 3-Chloro-2-methyl-1-propene | HCID 11241 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,3-Dihydro-2,2-dimethyl-7-benzofuranol | HCID 15278 | — |
| 生成物 | 7-Methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran | HCID 13531377 | — |
反応手順
The starting material 2,3-dihydro-2,2-dimethyl-7-benzofuranol is prepared from catechol and 3-chloro-2-methylpropene as described by Neth. No. 6,500,340. The material (16.4 g) is added to 125 ml of water and contacted with 8 ml of 50% NaOH. After stirring one-half hour, 16.4 g of dimethylsulfate is added and the resulting suspension is stirred and heated at 60° for 2 hours. The resulting mixture is extracted with methylene chloride. The organic phase is dried over sodium sulfate and the solvent is evaporated under reduced pressure. The residual oil is distilled to afford 2,3-dihydro-2,2-dimethyl-7-methoxybenzofuran.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04576632 |
| 出典データセット | uspto-grants-1986_03 |
| ORD ID | ord-cde4ca8fb730469395b1c40d09defc1a |
| 出典メモ | uspto-grants-1986_03 |