Chlorophenyl isocyanate → N-(2-Chlorophenyl)-N'-[4-(-1H-imidazol-1-yl)butyl]urea

HRID 482906ノート

反応式

HRID 482906 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[O:10].[N:11]1([CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH:15]=[CH:14][N:13]=[CH:12]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([NH:20][CH2:19][CH2:18][CH2:17][CH2:16][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1)=[O:10]

参加物

4

反応物 2

HCID 76833Chlorophenyl isocyanateHCID 43794804-(1H-imidazol-1-yl)butan-1-amine

生成物 1

HCID 13580008N-(2-Chlorophenyl)-N'-[4-(-1H-imidazol-1-yl)butyl]urea

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A solution of 2.30 g. of o-chlorophenyl isocyanate in 30 ml. of toluene was added with stirring to a solution of 2.09 g. of 1H-imidazole-1-butanamine in 20 ml. of toluene and the mixture was allowed to stir overnight and them evaporates to a crystalline residue. The crystals were dissolved in methylene chloride and purified by HPLC (silica gel column, eluted with 10% ethanol/ethyl acetate) to obtain the desired compound, mp. 87°-88° C.

後処理

  1. stirringto stir overnight
  2. customthem evaporates to a crystalline residue
  3. dissolutionThe crystals were dissolved in methylene chloride
  4. custompurified by HPLC (silica gel column, eluted with 10% ethanol/ethyl acetate)

出典と根拠

ORDレコード
ord-96b1d7cff994462ba8a25345dc491cdf
出典データセット
uspto-grants-1986_03
特許番号
US04576957

反応ノート

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