Chlorine → HCID 13336486、化合物

HRID 482910ノート

反応式

HRID 482910 の反応式
[CH3:1][NH:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[Cl:9]Cl>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[CH3:1][NH:2][C:3]1[C:7]([Cl:9])=[C:6]([CH3:8])[O:5][N:4]=1

参加物

5

反応物 2

HCID 24526ChlorineHCID 12580405N,5-Dimethyl-1,2-oxazol-3-amine

生成物 1

HCID 13336486HCID 13336486、化合物収率 84.6%

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 6344Dichloromethane溶媒

実験手順

Compound (15) (19.06 g) was dissolved in methylene chloride (150 ml) and a solution of chlorine (13.1 g) in carbon tetrachloride (139 ml) was added thereto dropwise. The mixture was stirred at room temperature for 10 minutes, then washed with a 50% potassium carbonate solution and water, dried and evaporated to give 3-methylamino-4-chloro-5-methylisoxazole (20) (21.07 g); mp. 43°-47° C.

後処理

  1. washwashed with a 50% potassium carbonate solution and water
  2. customdried
  3. customevaporated

出典と根拠

ORDレコード
ord-717f69be8dce46369d65d4da9bcfd252
出典データセット
uspto-grants-1986_03
特許番号
US04576956

反応ノート

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