Bromine → Ethanone, 2-bromo-1-[4-(methylthio)phenyl]-2-phenyl-

HRID 482912ノート

反応式

HRID 482912 の反応式
[C:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([S:16][CH3:17])=[CH:12][CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:18]Br>C(Cl)Cl.CCOCC>[Br:18][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:8]([C:10]1[CH:11]=[CH:12][C:13]([S:16][CH3:17])=[CH:14][CH:15]=1)=[O:9]

参加物

5

反応物 2

HCID 24408BromineHCID 27600881-(4-(methylthio)phenyl)-2-phenylethanone

生成物 1

HCID 11336208Ethanone, 2-bromo-1-[4-(methylthio)phenyl]-2-phenyl-収率 94.2%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a suspension of 30 g (0.12 mole) of 2-phenyl-1-(4-methylthiophenyl)ethanone in 45 ml of methylene chloride and 450 ml of ether was added dropwise a solution of 20.8 g (0.13 mole) of bromine in 65 ml of methylene chloride. The reaction mixture decolorized and became slightly exothermic. After stirring an additional 30 minutes, the reaction mixture was concentrated under vacuum. The crystalline product was collected by filtration and washed with hexane to give 36.3 g (91.5%) of 2-bromo-2-phenyl-1-(4-methylthiophenyl)ethanone as an off-white solid, m.p. 101°-103°.

後処理

  1. concentrationthe reaction mixture was concentrated under vacuum
  2. filtrationThe crystalline product was collected by filtration
  3. washwashed with hexane

出典と根拠

ORDレコード
ord-e728a761dbb645189b054173295207c2
出典データセット
uspto-grants-1986_03
特許番号
US04576958

反応ノート

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