3-Aminobenzoic Acid → 3-[(3-Ethoxyacryloyl)amino]benzoic acid

HRID 483150

反応式

HRID 483150 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:11]([O:13][CH:14]=[CH:15][C:16](Cl)=[O:17])[CH3:12]>CCOCC>[C:5]([C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][CH:8]=1)[NH:1][C:16](=[O:17])[CH:15]=[CH:14][O:13][CH2:11][CH3:12])([OH:7])=[O:6]

参加物

4

反応物 2

HCID 74193-Aminobenzoic AcidHCID 30144293-Ethoxy-2-propenoyl chloride

生成物 1

HCID 545354873-[(3-Ethoxyacryloyl)amino]benzoic acid

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

100 Grams of m-aminobenzoic acid was suspended in 1 liter of ether, then 44.6 g of β-ethoxyacrylyl chloride was added dropwise into the solution at a room temperature under stirring condition. This reaction mixture was kept at 40° C. for 5 hours, then the precipitate formed in the reaction mixture was collected by filtration. The crystals were washed with water three times, dried and recrystallized from methanol to obtain 60 g of m-carboxy-N-(β-ethoxyacryloyl)aniline in the form of colorless cotton-like crystals.

後処理

  1. customthe precipitate formed in the reaction mixture
  2. filtrationwas collected by filtration
  3. washThe crystals were washed with water three times
  4. customdried
  5. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-c9097c1091594a68afd2e5411c08ae4a
出典データセット
uspto-grants-1986_03
特許番号
US04578381

関連ノート

読み込み中…