Diketene → 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate

HRID 483192ノート

反応式

HRID 483192 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH2:7]([N:14]([CH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[CH3:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1C=CC=CC=1>[C:4]([O:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][N:14]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:15])(=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

参加物

4

反応物 2

HCID 12661DiketeneHCID 13422168HCID 13422168、化合物

生成物 1

HCID 101083403-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

One gram of diketen was added dropwise to a stirred solution of 3-(N-benzyl-N-methylamino)-2,2-dimethyl propanol in 1 ml of benzene at 70° C. Sturing was continued for 1.5 hours at 70° C. after the addition. The solvent was distilled off to leave an oily residue. The residue was chromatographed over silica gel to afford 2.8 g of desired 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate (oily substance).

後処理

  1. additionafter the addition
  2. distillationThe solvent was distilled off
  3. customto leave an oily residue
  4. customThe residue was chromatographed over silica gel

出典と根拠

ORDレコード
ord-9bf57e4daab84dd3bbcec133d8830958
出典データセット
uspto-grants-1986_03
特許番号
US04578395

反応ノート

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