Isopropanol → HCID 70456982、化合物

HRID 483199ノート

反応式

HRID 483199 の反応式
[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[NH2:13]/[C:14](/C)=[CH:15]\[C:16]([O:18][CH3:19])=[O:17].[C:21]([O:27][CH2:28][C:29]([CH3:41])([CH3:40])[CH2:30][N:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:32])(=[O:26])[CH2:22][C:23]([CH3:25])=O.[CH3:42]C(O)C>>[CH3:25][C:23]1([CH3:42])[CH:22]([C:21]([O:27][CH2:28][C:29]([CH3:41])([CH3:40])[CH2:30][N:31]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH3:32])=[O:26])[CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[C:3]=2[N+:10]([O-:12])=[O:11])[C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][NH:13]1

参加物

5

反応物 4

HCID 3776IsopropanolHCID 643918Methyl 3-aminocrotonateHCID 101083403-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetateHCID 122489723-CHLORO-2-NITROBENZALDEHYDE

生成物 1

HCID 70456982HCID 70456982、化合物

実験手順

A mixture of 185 mg of 3-chloro-2-nitrobenzaldehyde, 118 mg of methyl 3-aminocrotonate and 292 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 1 ml of 2-propanol was refluxed for 12 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a method of column chromatography on silica gel to yield 337 mg of the desired compound (132).

後処理

  1. temperaturewas refluxed for 12 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified by a method of column chromatography on silica gel

出典と根拠

ORDレコード
ord-7c373083ce3d4fbb96d390ffc50abd9a
出典データセット
uspto-grants-1986_03
特許番号
US04578395

反応ノート

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