2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepine-5(4H)-one → 2-[(dimethylamino)methyl]2,3-dihydro-4-methylpyrido[3,2-f][1,4]oxazepin-5(4H)-one

HRID 4832

反応式

HRID 4832 の反応式
Cl[CH2:2][CH:3]1[CH2:9][N:8]([CH3:10])[C:7](=[O:11])[C:6]2[CH:12]=[CH:13][CH:14]=[N:15][C:5]=2[O:4]1.ClCCC1[CH2:25][N:24](C)[C:23](=O)C2C=CC=NC=2O1>>[CH3:23][N:24]([CH2:2][CH:3]1[CH2:9][N:8]([CH3:10])[C:7](=[O:11])[C:6]2[CH:12]=[CH:13][CH:14]=[N:15][C:5]=2[O:4]1)[CH3:25]

参加物

3

反応物 2

HCID 137264362-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepine-5(4H)-oneHCID 212715882-chloromethyl-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepin-5(4H)-one

生成物 1

HCID 136894292-[(dimethylamino)methyl]2,3-dihydro-4-methylpyrido[3,2-f][1,4]oxazepin-5(4H)-one

実験手順

When in the procedure of Example 10, 2-chloromethyl-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepin-5(4H)-one is substituted for 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepin-5(4H)-one, the title compound is prepared and is isolated if desired as a pharmaceutically acceptable salt.

後処理

  1. customis isolated

出典と根拠

ORDレコード
ord-f2ced41ca80546fca5cc841a48e387ac
出典データセット
uspto-grants-1988_02
特許番号
US04727152

関連ノート

読み込み中…