化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 5-[(4-Nitrophenyl)methyl]imidazolidine-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Nitro-3-phenyl-L-alanine | HCID 13706 | — |
| 反応物 | Potassium cyanate | HCID 11378442 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-[(4-Nitrophenyl)methyl]imidazolidine-2,4-dione | HCID 10466579 | 82% |
反応手順
A solution of p-nitrophenylalanine (4.2 g, Fluka) and potassium cyanate (1.62 g) in water (6 ml) was refluxed for 1 hour. C.HCl (3 ml) was added and the mixture refluxed for a further 10 minutes, then cooled, diluted with water and filtered. The residue was washed with water and dried to give the desired product as a straw-coloured solid (3.85 g). The 200 MHz 1H NMR was consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05225431 |
| 出典データセット | uspto-grants-1993_07 |
| ORD ID | ord-62efc28f41c543b7913ba1e431fd9ca5 |
| 出典メモ | uspto-grants-1993_07 |