Hydrochloric Acid → 4-nitro- DL-Phenylalanine, methyl ester, monohydrochloride

HRID 483386ノート

反応式

HRID 483386 の反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:16].[CH3:17]O>>[ClH:16].[NH2:10][CH:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:15][CH:14]=1)[C:11]([O:13][CH3:17])=[O:12]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 137064-Nitro-3-phenyl-L-alanine

生成物 1

HCID 533959764-nitro- DL-Phenylalanine, methyl ester, monohydrochloride

実験手順

A solution of p-nitro-L-phenylalanine (12.6 g) and c.HCl (7.5 g) in methanol (150 ml) was refluxed for 1.5 hours and the solvent then evaporated in vacuo. The residue was triturated with ether and recrystallised from SVM to give the desired product as a off-white solid, [α]25 +15.3° (c=0.55, MeOH).

後処理

  1. customthe solvent then evaporated in vacuo
  2. customThe residue was triturated with ether
  3. customrecrystallised from SVM

出典と根拠

ORDレコード
ord-71a8162ecd834347b161bb44eb91ad7d
出典データセット
uspto-grants-1993_07
特許番号
US05225431

反応ノート

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