関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dibutyltin oxide | HCID 61221 | — |
| 反応物 | 1-Methyl-2-piperidinemethanol | HCID 89394 | — |
| 反応物 | Ethyl 1-methylpiperidine-2-carboxylate | HCID 566742 | — |
| 生成物 | N-Methyl-(2-piperidyl)methyl N-Methylpipecolinate | HCID 67804823 | — |
反応手順
A mixture of 85.6 g (0.5 mole) of ethyl 1-methylpipecolinate, 64.6 g (0.5 mole) of 1-methyl-2piperidinemethanol and 1.1 g dibutyltin oxide was heated at 130° C. for three hours and then gradually heated to 200° C. When the amount of ethanol collected indicated the reaction was essentially complete the liquid product, N-methyl-(2-piperidyl)methyl N-methylpipecolinate, was distilled at 0.25 mm Hg pressure at about 130° C. The nuclear magnetic resonance and infrared spectra of the product were consistent with the structural assignment.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05225513 |
|---|
| 出典データセット | uspto-grants-1993_07 |
|---|
| ORD ID | ord-d8a66124e98e4159af20384ffa2791a0 |
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| 出典メモ | uspto-grants-1993_07 |
|---|
