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Diisopropyl Ether → N-(beta-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 反応物 | N-Phenyl-1-(phenylmethyl)-4-piperidinamine | HCID 70865 | — |
| 反応物 | 3-Ethoxy-2-propenoyl chloride | HCID 3014429 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-(beta-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline | HCID 54194521 | 89.3% |
反応手順
To a mixture of N-(1-benzyl-4-piperidinyl)aniline (0.9 g), diisopropyl ether (30 ml) and triethylamine (0.5 g) is added β-ethoxyacrylic acid chloride (0.7 g) in portions at 60° C. After refluxing for 1 hour, the reaction mixture is poured into ice-water and extracted with ethyl acetate. The extract is dried and concentrated and to the resulting residue is added n-hexane and the formed crystals are separated by filtration and recrystallized from n-hexane to give N-(β-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline (1.1 g) as white powders, m.p. 106°-108° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05225402 |
| 出典データセット | uspto-grants-1993_07 |
| ORD ID | ord-0a112829de304f8a85fdf8e713e3ee0b |
| 出典メモ | uspto-grants-1993_07 |