Ammonia → 2-[4-(2-Aminoethyl)phenyl]ethylamine
反応式
[C:1]1([CH2:10][C:11]#[N:12])[CH:6]=[CH:5][C:4]([CH2:7][C:8]#[N:9])=[CH:3][CH:2]=1.N.[H][H]>[Ni].CO>[NH2:9][CH2:8][CH2:7][C:4]1[CH:5]=[CH:6][C:1]([CH2:10][CH2:11][NH2:12])=[CH:2][CH:3]=1参加物
6
実験手順
Scheme I, step B′: Into a 250 mL reduction vessel were placed 1,4-phenylenediacetonitrile (10 g, 64.02 mmol), liquid ammonia (25 mL), and W4-W6 range (medium range activity) Raney Nickel (1.25 g) in methanol (125 mL), and the mixture was heated at 100° C. under 300 psi (2068 kPa) of hydrogen gas for 10 hours. The reaction was cooled to room temperature and filtered through a Celite® cake and the filtrate was concentrated under reduced vacuum to give the intermediate title compound, 2-[4-(2-aminoethyl)phenyl]ethylamine, (10.3 g, 98%) as an oil. Electron spray M.S. 165 (M*+H).
後処理
- customScheme I, step B′: Into a 250 mL reduction vessel were placed
- filtrationfiltered through a Celite® cake
- concentrationthe filtrate was concentrated under reduced vacuum
出典と根拠
- ORDレコード
- ord-80862a1fbb344d8d94617c30b01cc0a7
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703425B2
反応ノート
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