化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylmorpholine → Boc-gly-pro-OH
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | N-(tert-Butyloxycarbonyl)glycine N-hydroxysuccinimide ester | HCID 76926 | — |
| 反応物 | L-Proline | HCID 145742 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Boc-gly-pro-OH | HCID 11673468 | — |
反応手順
1.4 ml (11 mmol) of N-methylmorpholine are added to 1.15 g (10 mmol) of proline in 50 ml of DMF. The mixture is cooled with an ice bath, 3.06 g (10 mmol) of Boc-Gly-OSu are then added and the pH is adjusted to between 6 and 7 throughout the reaction (14 h) by successive additions of small amounts of N-methylmorpholine (this substance is used as a proton acceptor). The DMF is evaporated off and the evaporation residue is taken up with AcOEt; after precipitation in petroleum ether and then filtration, the expected product is collected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05225532 |
| 出典データセット | uspto-grants-1993_07 |
| ORD ID | ord-46a95c7b3d8442cca33271779bfafde1 |
| 出典メモ | uspto-grants-1993_07 |