Methanol, 1-methoxy-, 1-acetate → 1,3-Dipivaloyl-2-methoxymethyl glycerol

HRID 483674ノート

反応式

HRID 483674 の反応式
[C:1]([O:7][CH2:8][CH:9]([CH2:11][O:12][C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])[OH:10])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.[C:31]([O:34][CH2:35]OC)(=O)C>CCCCCC>[C:1]([O:7][CH2:8][CH:9]([CH2:11][O:12][C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])[O:10][CH2:31][O:34][CH3:35])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

参加物

5

反応物 3

HCID 78087Methanol, 1-methoxy-, 1-acetateHCID 521998p-Toluenesulfonic acid monohydrateHCID 136911551,3-Dipivaloyl glycerol

生成物 1

HCID 109796251,3-Dipivaloyl-2-methoxymethyl glycerol

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

50.45 g of 1,3-dipivaloyl glycerol was dissolved in 200 ml of methoxymethyl acetate. After the addition of 2.5 g of p-toluenesulfonic acid monohydrate, the mixture was stirred for 1 hr then diluted with 200 ml of hexane and washed twice with 200 ml saturated aqueous sodium carbonate, once with aqueous NaCl solutions, dried over anhydrous magnesium sulfate and concentrated in vacuo to afford 1,3-dipivaloyl-2-methoxymethyl glycerol as a colorless oil.

後処理

  1. washwashed twice with 200 ml saturated aqueous sodium carbonate, once with aqueous NaCl solutions
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ce832fdd316046a394efeca9e7a52d66
出典データセット
uspto-grants-1993_07
特許番号
US05225590

反応ノート

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