Arecoline → 3-Methoxycarbonyl-1-methyl-4-(3-trifluoromethylphenyl)piperidine

反応式

[CH3:1][N:2]1[CH2:7][C:6]([C:8]([O:10][CH3:11])=[O:9])=[CH:5][CH2:4][CH2:3]1.Br[C:13]1[CH:14]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:17][CH:18]=1>>[CH3:11][O:10][C:8]([CH:6]1[CH:5]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7]1)=[O:9]

参加物

反応物 2

HCID 2230Arecoline

HCID 9817Benzene, 1-bromo-3-(trifluoromethyl)-

生成物 1

HCID 197512613-Methoxycarbonyl-1-methyl-4-(3-trifluoromethylphenyl)piperidine

実験手順

3-methoxycarbonyl-1-methyl-4-(3-trifluoromethylphenyl)piperidine was prepared as the cis/trans mixture from arecoline and 3-bromo-trifluoromethylbenzene as described (J. Org. Chem. 22 (1957) 261). The product was purified by vacuum distillation. B.p. 90°-110° C./0.7 mmHg.

後処理

distillationThe product was purified by vacuum distillation

出典と根拠

ORDレコード: ord-1a232e0c4acd4c8195c3f74b996ba32d
出典データセット: uspto-grants-1993_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05227379

反応ノート

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