関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyrazole | HCID 1048 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 8-Aza-5-azoniaspiro(4.5)decane, 8-(2-pyrimidinyl)-, bromide (1:1) | HCID 657505 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole | HCID 11044366 | — |
反応手順
A mixture of 730 g (3.59 moles) of 8-(2-pyrimidinyl)-8-aza-5-azoniaspiro[4,5]decane bromide, 275 g (4.05 moles) of pyrazole and 745 g (5.4 moles) of potassium carbonate in 3 1 of dimethylformamide is heated to 140° C. for 14 hours. The mixture is evaporated under vacuum, chloroform is added, the solution is washed with water, dried over sodium sulfate and evaporated under vacuum, and 650 g (94%) of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole are obtained in liquid form.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05227486 |
|---|
| 出典データセット | uspto-grants-1993_07 |
|---|
| ORD ID | ord-00438c32cf89405f95ce1ee33dcba21e |
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| 出典メモ | uspto-grants-1993_07 |
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