2-Aminoindane → 4-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine

HRID 48398

反応式

HRID 48398 の反応式
Cl[C:2]1[C:3]2[C:10]([CH3:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1>C(O)C>[CH2:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:21][CH:13]1[NH:12][C:2]1[C:3]2[C:10]([CH3:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1

参加物

4

反応物 2

HCID 763102-AminoindaneHCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidine

生成物 1

HCID 99257354-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-chloro-5-methylthieno[2,3-d]pyrimidine (92 mg, 0.50 mmol) (see J. Pharm. Soc. JAPAN, 109, 464 (1989)) and 2-aminoindan (330 mg, 2.5 mmol) in dry ethanol (1 ml) were heated to reflux under an argon atmosphere for 40 minutes. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to obtain the title compound (140 mg, 0.50 mmol) having the following physical properties:

後処理

  1. temperatureto reflux under an argon atmosphere for 40 minutes
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue obtained
  4. customwas purified by silica gel chromatography (hexane:ethyl acetate=5:1)

出典と根拠

ORDレコード
ord-2dd1b64c46964b598edb3b42f0923799
出典データセット
uspto-grants-2004_03
特許番号
US06703421B1

関連ノート

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