Ammonia → 3-Aminopropyl(n-butyl)phosphinic acid ethyl ester
反応式
[CH2:1]([O:3][P:4]([CH2:10][CH2:11][C:12]#[N:13])([CH2:6][CH2:7][CH2:8][CH3:9])=[O:5])[CH3:2].N>C(O)C.[Ni]>[CH2:1]([O:3][P:4]([CH2:10][CH2:11][CH2:12][NH2:13])([CH2:6][CH2:7][CH2:8][CH3:9])=[O:5])[CH3:2]参加物
5
実験手順
16.46 g of 2-cyanoethyl(n-butyl)phosphinic acid ethyl ester are dissolved in 165 ml of ethanol, the solution is mixed with 16.5 g of ammonia and 3.0 g of Raney nickel, and the mixture is hydrogenated for 2 hours at 70°-75° under an initial pressure of 100 bar. The mixture is allowed to cool to room temperature, the catalyst is filtered off, the solvent is removed and the residue is distilled, yielding 3-aminopropyl(n-butyl)phosphinic acid ethyl ester having a boiling point of 100° (10-5 bar).
後処理
- filtrationthe catalyst is filtered off
- customthe solvent is removed
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-a534f987a31441fe8cbc9b5bc87c3871
- 出典データセット
- uspto-grants-1993_07
- 特許番号
- US05229379
反応ノート
読み込み中…