Potassium Carbonate → 1-(Benzimidazol-2-yl)-4-aminomethylpiperidine

HRID 484057ノート

反応式

HRID 484057 の反応式
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

生成物 1

HCID 197495451-(Benzimidazol-2-yl)-4-aminomethylpiperidine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

45 g of 4-aminomethylpiperidine are placed 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

後処理

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

出典と根拠

ORDレコード
ord-4657c9f99e1c4e2ea18372ccbc0a787b
出典データセット
uspto-grants-1993_07
特許番号
US05229398

反応ノート

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