Potassium Carbonate → 1-(Benzimidazol-2-yl)-4-aminomethylpiperidine

HRID 484061ノート

反応式

HRID 484061 の反応式
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

生成物 1

HCID 197495451-(Benzimidazol-2-yl)-4-aminomethylpiperidine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

45 g of 4-aminomethylpiperidine are placed in 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

後処理

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

出典と根拠

ORDレコード
ord-be580a30a9b34f9bbed5e1bf558fbc35
出典データセット
uspto-grants-1993_07
特許番号
US05229399

反応ノート

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