Triethylamine → 9-[3'-(Isopropylaminocarbonyloxymethyl)-anilino]-2,7-dimethoxyacridine

HRID 484087ノート

反応式

HRID 484087 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[NH:6][C:7]1[C:8]2[C:13]([N:14]=[C:15]3[C:20]=1[CH:19]=[C:18]([O:21][CH3:22])[CH:17]=[CH:16]3)=[CH:12][CH:11]=[C:10]([O:23][CH3:24])[CH:9]=2.[CH:28]([N:31]=[C:32]=[O:33])([CH3:30])[CH3:29].C(N(CC)CC)C>C(Cl)Cl>[CH:28]([NH:31][C:32]([O:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[NH:6][C:7]1[C:8]2[C:13]([N:14]=[C:15]3[C:20]=1[CH:19]=[C:18]([O:21][CH3:22])[CH:17]=[CH:16]3)=[CH:12][CH:11]=[C:10]([O:23][CH3:24])[CH:9]=2)=[O:33])([CH3:30])[CH3:29]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 61277Isopropyl isocyanateHCID 19749149HCID 19749149、化合物

生成物 1

HCID 197494999-[3'-(Isopropylaminocarbonyloxymethyl)-anilino]-2,7-dimethoxyacridine収率 84%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 9-(3'-hydroxymethylanilino)-2,7-dimethoxyacridine, (300 mg, 0.66 mmol), isopropyl isocyanate (1 ml) and triethylamine (2 ml) in methylene chloride (20 ml) is stirred at room temperature for 90 minutes, and then concentrated in vacuo. The residue is chromatographed on a silica gel column using commerical chloroform as the eluent to give the 9-[3'-(isopropylaminocarbonyloxymethyl)-anilino]-2,7-dimethoxyacridine, (246 mg, 84%) as a yellow solid, mp 148°-149° C.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue is chromatographed on a silica gel column

出典と根拠

ORDレコード
ord-2c6c5ec64e9f43f29d6b28bb62d13f9f
出典データセット
uspto-grants-1993_07
特許番号
US05229395

反応ノート

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