Acetic Acid → 2,6-Dihydroxyethylaminotoluene

HRID 484265ノート

反応式

HRID 484265 の反応式
ClCCON[C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16](=O)NOCCCl)[C:10]=1[CH3:23])=O.[OH-:24].[K+].[C:26]([OH:29])(=O)C.[CH3:30]O>O>[OH:24][CH2:30][CH2:16][NH:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([NH:8][CH2:6][CH2:26][OH:29])[C:10]=1[CH3:23]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 19746917HCID 19746917、化合物

生成物 1

HCID 101305242,6-Dihydroxyethylaminotoluene

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

33.5 g of the 2,6-bis(β-chloroethoxycarbamoylamino)toluene obtained above under the 1st stage are initially introduced into the reaction vessel in 200 ml of water and 30 ml of methanol. The reaction mixture is heated to 75° C. and 70 g of 50% strength potassium hydroxide solution are added dropwise in the course of one hour. After the mixture has been subsequently stirred at 60° C. for 21/2 hours, the pH is brought to 8.0 with glacial acetic acid and the reaction mixture is cooled slowly. The product which has precipitated is filtered off with suction, washed with water, and dried at 50° C. in a vacuum cabinet.

後処理

  1. temperaturethe reaction mixture is cooled slowly
  2. customThe product which has precipitated
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried at 50° C. in a vacuum cabinet

出典と根拠

ORDレコード
ord-bf71a19806ae4cf2853e2b718c4b1e1e
出典データセット
uspto-grants-1993_07
特許番号
US05230710

反応ノート

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