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Hydrochloric Acid → 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-((methoxyimino)methyl)-, 2-propenyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Allyl chloroformate | HCID 18052 | — |
| 反応物 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime | HCID 197313 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-((methoxyimino)methyl)-, 2-propenyl ester | HCID 9588799 | — |
反応手順
To a solution of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde-O-methyloxime in 40 cm3 of benzene, 1.5 cm3 of triethylamine and 1.17 cm3 of 2-propenyl chloroformate are added. The mixture is agitated for 30 minutes at ambient temperature, then treated with 20 cm3 of 5% hydrochloric acid, then twice with 20 cm3 of water. The solvent is evaporated off, then the residue is distilled at 200° C. under 0.08 mbar. 2.25 g of the expected product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05231107 |
| 出典データセット | uspto-grants-1993_07 |
| ORD ID | ord-25147420e1184deca8676bc11f13bfdc |
| 出典メモ | uspto-grants-1993_07 |