Triethylamine → 4-(4-Methoxycarbonylindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine

HRID 48439

反応式

HRID 48439 の反応式
Cl.[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:12]([O:14][CH3:15])=[O:13])[CH2:4]1.Cl[C:17]1[C:18]2[C:25]([CH3:26])=[CH:24][S:23][C:19]=2[N:20]=[CH:21][N:22]=1.C(N(CC)CC)C>C(O)C>[CH3:15][O:14][C:12]([C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH2:11][CH:3]([NH:2][C:17]1[C:18]3[C:25]([CH3:26])=[CH:24][S:23][C:19]=3[N:20]=[CH:21][N:22]=1)[CH2:4]2)=[O:13]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 227196362-Amino-4-methoxycarbonylindan hydrochloride

生成物 1

HCID 227195834-(4-Methoxycarbonylindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Using 2-(tert-butoxycarbonylamino)-4-methoxycarbonylindan (45 mg, 0.15 mmol) synthesized in the above Reference Production Example 7, 4N hydrochloric acid-dioxane (0.7 ml) and acetic acid (2.1 ml), a similar procedure to Production Example 213 was carried out to obtain 2-amino-4-methoxycarbonylindan hydrochloride. Then, using the 2-amino-4-methoxycarbonylindan hydrochloride, 4-chloro-5-methylthieno[2,3-d]pyrimidine (28 mg, 0.15 mmol), triethylamine (63 μl, 0.45 mmol), and ethanol (1 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (15 mg, 0.044 mmol) having the following physical properties:

後処理

  1. customThe product obtained
  2. customwas purified by silica gel chromatography (hexane:ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-cf637972c84744d1916819fccc028d61
出典データセット
uspto-grants-2004_03
特許番号
US06703421B1

関連ノート

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