Formamide → HCID 178518030、化合物

HRID 48447

反応式

HRID 48447 の反応式
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[NH2:10])=O.[CH:11]([NH2:13])=O>O>[OH:2][C:3]1[C:5]2[S:6][CH:7]=[CH:8][C:9]=2[N:10]=[CH:11][N:13]=1

参加物

4

反応物 2

HCID 713FormamideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

生成物 1

HCID 178518030HCID 178518030、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 °C

実験手順

3-aminothiophene-2-carboxylic acid methylester (1.6 g, 10 mmol) was added to formamide (3.4 ml), and the mixture was stirred at 200° C. for 2 hours. The reaction mixture was returned to room temperature, and water was added thereto, which was extracted with chloroform. The solid obtained by distilling off the solvent under reduced pressure was washed with ethyl acetate to obtain 4-hydroxythieno[3,2-d]pyrimidine (60 mg, 0.39 mmol).

後処理

  1. customwas returned to room temperature
  2. extractionwhich was extracted with chloroform
  3. customThe solid obtained
  4. distillationby distilling off the solvent under reduced pressure
  5. washwas washed with ethyl acetate

出典と根拠

ORDレコード
ord-acd8ccb1d4e34ab0a44c61593a48bc0e
出典データセット
uspto-grants-2004_03
特許番号
US06703421B1

関連ノート

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