Formamide → HCID 178518030、化合物
反応式
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[NH2:10])=O.[CH:11]([NH2:13])=O>O>[OH:2][C:3]1[C:5]2[S:6][CH:7]=[CH:8][C:9]=2[N:10]=[CH:11][N:13]=1参加物
4
反応条件
- 温度
- 200 °C
実験手順
3-aminothiophene-2-carboxylic acid methylester (1.6 g, 10 mmol) was added to formamide (3.4 ml), and the mixture was stirred at 200° C. for 2 hours. The reaction mixture was returned to room temperature, and water was added thereto, which was extracted with chloroform. The solid obtained by distilling off the solvent under reduced pressure was washed with ethyl acetate to obtain 4-hydroxythieno[3,2-d]pyrimidine (60 mg, 0.39 mmol).
後処理
- customwas returned to room temperature
- extractionwhich was extracted with chloroform
- customThe solid obtained
- distillationby distilling off the solvent under reduced pressure
- washwas washed with ethyl acetate
出典と根拠
- ORDレコード
- ord-acd8ccb1d4e34ab0a44c61593a48bc0e
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703421B1
反応ノート
読み込み中…