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4-[Bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine → 4-(Bis(4-fluorophenyl)methylene)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[Bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine | HCID 13519965 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(Bis(4-fluorophenyl)methylene)piperidine | HCID 2724436 | — |
反応手順
A mixture of 1.6 parts of 4-[bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine and 80 parts of methanol was hydrogenated at normal pressure and at room temperature with 1 part of rhodium-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 1.2 parts of 4-[bis(4-fluorophenyl)methylene]piperidine as a residue (intermediate 14).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04533665 |
| 出典データセット | uspto-grants-1985_08 |
| ORD ID | ord-f88207d3b9354acea8607188c4eb2351 |
| 出典メモ | uspto-grants-1985_08 |