2-Methylpropylenediamine → 5,5-Dimethylpiperazin-2-one

反応式

COC(=O)C(Br)[CH2:5][CH:6]([CH3:8])[CH3:7].NCC(N)(C)C.[CH3:17][C:18]1([CH3:29])[NH:23][C:22](=[O:24])[CH:21](CC(C)C)[NH:20][CH2:19]1>>[CH3:7][C:6]1([CH3:8])[CH2:5][NH:23][C:22](=[O:24])[CH2:21][NH:20]1.[CH3:17][C:18]1([CH3:29])[NH:23][C:22](=[O:24])[CH2:21][NH:20][CH2:19]1

参加物

反応物 3

HCID 131282-Methylpropylenediamine

HCID 12957039Methyl 2-bromo-4-methylpentanoate

HCID 135203836,6-Dimethyl-3-(2-methylpropyl)piperazinone

生成物 2

HCID 233196555,5-Dimethylpiperazin-2-one

HCID 233196856,6-Dimethylpiperazin-2-one

実験手順

Following the general procedure of Example 4 and making non-critical variations, but substituting ethyl chloroacetate (VI) for methyl 2-bromo-4-methylpentanoate (V) and 1,2-diamino-2-methylpropane (VI) for ethylenediamine (VII) there are obtained 5,5-dimethylpiperazinone and 6,6-dimethylpiperazinone.