4-Fluorobenzoyl chloride → 4-Fluoro-N-(4-methyl-2-oxopentyl)benzamide

HRID 485025ノート

反応式

HRID 485025 の反応式
Cl.[C:2]([CH2:8][NH2:9])(=[O:7])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)(O)[O-].[Na+].[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH:9][CH2:8][C:2](=[O:7])[CH2:3][CH:4]([CH3:6])[CH3:5])=[O:21])=[CH:18][CH:17]=1

参加物

4

反応物 3

HCID 678794-Fluorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 137017551-Amino-4-methylpentan-2-one hydrochloride

生成物 1

HCID 134903084-Fluoro-N-(4-methyl-2-oxopentyl)benzamide収率 93%

実験手順

2.75 g of isovalerylmethylamine hydrochloride, 3.8 g of sodium bicarbonate and 3.16 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(4). 4.0 g of N-(4-fluorobenzoyl)isovalerylmethylamine are thereby obtained. Yield: 82.9%.

後処理

  1. customas described in Preparation 1-(4)

出典と根拠

ORDレコード
ord-f02114539136430da32867c9d46a0e75
出典データセット
uspto-grants-1985_08
特許番号
US04535089

反応ノート

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