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Trifluoroacetic acid → N-Carbobenzoxysarcosine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Triethylsilane | HCID 12052 | — |
| 反応物 | Benzyloxycarbonylglycine | HCID 14349 | — |
| 反応物 | 2-Oxazolidinone | HCID 73949 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-Carbobenzoxysarcosine | HCID 97053 | 48% |
反応手順
The oxazolidinone from Cbz-glycine (221 mg, 1.0 mmole) was dissolved in 10 ml of CHCl3 and triethylsilane (193 ∥l=174 mg, 1.5 mmoles) and trifluoroacetic acid (770 μl, 10 mmoles) were added. The solution was stirred at room temperature for 2 hrs. and concentrated in vacuo. CHCl3 was added and the solution was reconcentrated to a colorless oil. Silica gel chromatography gave 107 mg (48%) of Cbz-sarcosine, identified by NMR (N-Me, 2.98 ppm) and amino acid analysis.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04535167 |
| 出典データセット | uspto-grants-1985_08 |
| ORD ID | ord-9817e6cc60184ba48a7cc56b80e3695f |
| 出典メモ | uspto-grants-1985_08 |