Sodium Acetate → 2-Methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl acetate

HRID 485120ノート

反応式

HRID 485120 の反応式
C(O[C:5]1([CH3:14])[CH:9]=[CH:8][C:7](=[O:10])[CH:6]1[CH2:11][CH:12]=[CH2:13])(=O)C.[C:15]([O-:18])(=[O:17])[CH3:16].[Na+]>C(O)(=O)C>[C:15]([O:18][CH:9]1[CH2:8][C:7](=[O:10])[C:6]([CH2:11][CH:12]=[CH2:13])=[C:5]1[CH3:14])(=[O:17])[CH3:16]

参加物

4

反応物 2

HCID 517045Sodium AcetateHCID 13335393HCID 13335393、化合物

生成物 1

HCID 131027602-Methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl acetate収率 176.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

Into a four necked flask equipped with an agitator and a thermometer, 3-acetoxy-2-allyl-3-methyl-4-cyclopentenone (19.4 g), acetic acid (80 ml) and sodium acetate (4 g) were charged and refluxed for 5 hours with agitation. After the completion of the reaction, acetic acid was evaporated off under reduced pressure. The residue was shaken with toluene (70 ml) and water (40 ml). The organic layer was separated, washed with an aqueous solution of sodium bicarbonate and then water and concentrated. The residue was distilled to obtain 4-acetoxy-2-allyl-3-methyl-2-cyclopentenone (16.7 g). Yield, 86%. B.P., 100°-110° C./0.1-0.3 mmHg.

後処理

  1. customInto a four necked flask equipped with an agitator
  2. temperaturerefluxed for 5 hours with agitation
  3. customwas evaporated off under reduced pressure
  4. customThe organic layer was separated
  5. washwashed with an aqueous solution of sodium bicarbonate
  6. concentrationwater and concentrated
  7. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-83a2d24f388e4c3ea1585f823b98d8f1
出典データセット
uspto-grants-1985_08
特許番号
US04535182

反応ノート

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