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Sodium Iodide → Ethyl 4-(4-benzofuranyloxymethyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 4-(bromomethyl)benzoate | HCID 954261 | — |
| 反応物 | 4-Benzofuranol | HCID 11607921 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | Ethyl 4-(4-benzofuranyloxymethyl)benzoate | HCID 13092102 | — |
反応手順
4-Hydroxybenzofuran (1.34 g, 0.01 M), ethyl 4-bromomethylbenzoate (2.43 g, 0.01 M), anhydrous potassium carbonate (1.49 g), sodium iodide (0.05 g) and 95% ethanol (10 ml) were refluxed with stirring (5 hr). The cooled reaction mixture was diluted with 0.5 N sodium hydroxide solution and cooled in ice. The precipitated solid was filtered off, washed well with water and recrystallised form ethanol-water to give ethyl 4-(4-benzofuranyloxymethyl)benzoate, m.p. 70°-72° C. (Found: C, 72.79; H, 5.46. C18H16O4 requires C, 72.96; H, 5.44%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04535183 |
| 出典データセット | uspto-grants-1985_08 |
| ORD ID | ord-aba515183f024d00a5a792158bb69827 |
| 出典メモ | uspto-grants-1985_08 |