Methanol → HCID 131713679、化合物

HRID 485187ノート

反応式

HRID 485187 の反応式
[C:1]([NH:9][C@@H:10]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:11](=[O:30])[CH2:12][NH:13][C@H:14]([C:16]([N:18]1[CH2:29][CH2:28][CH2:27][C@H:19]1[C:20]([O:22]C(C)(C)C)=[O:21])=[O:17])[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:38].N1CCC[C@H]1C(O)=O.CO.C(O)CCC.C(O)(=O)C.O>Cl.C(O)(=O)C>[ClH:38].[C:1]([NH:9][C@@H:10]([CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:11](=[O:30])[CH2:12][NH:13][C@H:14]([C:16]([N:18]1[CH2:29][CH2:28][CH2:27][C@H:19]1[C:20]([OH:22])=[O:21])=[O:17])[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 887MethanolHCID 10285808Proline hydrochloride, L-HCID 141273661-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, 1,1-dimethylethyl esterHCID 22056973Butanol acetic acid water

生成物 1

HCID 131713679HCID 131713679、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 313Hydrochloric Acid溶媒

実験手順

1-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, 1,1-dimethylethyl ester (740 mg., 1.46 mmole) is dissolved in a solution of hydrogen chloride in acetic acid (1.5N, 10 ml.) and kept at room temperature for 30 minutes. It is then concentrated, taken into water, filtered and lyophilized to obtain 600 mg. of 1-[N-(S)-3-(benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, monohydrochloride; m.p. 83°-163°; [α]D25 =-109° (c=1.04, methanol). Rf 0.6 (silica gel; butanol/acetic acid/water, 4:1:1).

後処理

  1. concentrationIt is then concentrated
  2. filtrationfiltered
  3. customto obtain 600 mg

出典と根拠

ORDレコード
ord-244be213176e4281b3c133665b57ae3d
出典データセット
uspto-grants-1985_08
特許番号
US04535176

反応ノート

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