4,4'-Diethylbenzophenone → Ethyl 4-[3,3-bis-(p-tolyl)propionamido]benzoate
反応式
C(OP(CC(NC1C=CC(C(OCC)=O)=CC=1)=O)(OCC)=O)C.C(C1C=CC(C(C2C=CC(CC)=CC=2)=O)=CC=1)C.[C:42]1([CH3:71])[CH:47]=[CH:46][C:45]([C:48]([C:64]2[CH:69]=[CH:68][C:67]([CH3:70])=[CH:66][CH:65]=2)=[CH:49][C:50]([NH:52][C:53]2[CH:63]=[CH:62][C:56]([C:57]([O:59][CH2:60][CH3:61])=[O:58])=[CH:55][CH:54]=2)=[O:51])=[CH:44][CH:43]=1>>[C:42]1([CH3:71])[CH:43]=[CH:44][C:45]([CH:48]([C:64]2[CH:65]=[CH:66][C:67]([CH3:70])=[CH:68][CH:69]=2)[CH2:49][C:50]([NH:52][C:53]2[CH:63]=[CH:62][C:56]([C:57]([O:59][CH2:60][CH3:61])=[O:58])=[CH:55][CH:54]=2)=[O:51])=[CH:46][CH:47]=1参加物
実験手順
Certain of the compounds of this invention are prepared directly by the reaction of substituted diethyl phosphonoacetanilides with benzophenones. The requisite substituted diethyl phonsphonoacetanilides are prepared as follows. Treatment of bromoacetyl bromide with a substituted aniline yields a substituted bromoacetanilide. Reaction of the bromoacetanilide with triethylphosphite affords the substituted diethyl phosphonoacetanilide required for reaction with a benzophone. An example of this series of reactions is the acylation of ethyl 4-aminobenzoate to yield ethyl 4-bromoacet anilide followed by reaction with triethyl phosphite to yield ethyl 4-[(diethylphosphono)acetamido]benzoate. Reaction of this diethylphosphonoacetanilide with 4,4'-diethylbenzophenone then affords ethyl 4-[3,3-bis-(p-tolyl)acrylamido]benzoate directly. If the saturated analog is desired, catalytic hydrogenation of this ester may be used to obtain ethyl 4-[3,3-bis-(p-tolyl)propionamido]benzoate.
出典と根拠
- ORDレコード
- ord-06ac7febf697470f80400742da9787d9
- 出典データセット
- uspto-grants-1985_08
- 特許番号
- US04536346
反応ノート
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