Phosgene → 2,3-Dihydro-1H-pyrrolizine-5-carbonyl chloride

HRID 485367ノート

反応式

HRID 485367 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[CH2:5]1[C:12]2[N:8]([CH:9]=[CH:10][CH:11]=2)[CH2:7][CH2:6]1>C1(C)C=CC=CC=1.CCOCC>[CH2:11]1[C:12]2[N:8]([C:7]([C:1]([Cl:4])=[O:2])=[CH:6][CH:5]=2)[CH2:9][CH2:10]1

参加物

5

反応物 2

HCID 6371PhosgeneHCID 2593612,3-Dihydro-1H-pyrrolizine

生成物 1

HCID 134904052,3-Dihydro-1H-pyrrolizine-5-carbonyl chloride

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a stirred, ice-bath cooled portion (30 ml) of 12.5% phosgene in toluene was added a solution of 2,3-dihydro-1H-pyrrolizine (0.80 g, 0.0074 m) in ether (30 ml) dropwise over ca two minutes. After stirring cold for ca 2.5 hr, the reaction mixture is allowed to warm to room temperature, the volatiles are removed in vacuo, and the resultant crystalline 2,3-dihydro-1H-pyrrolizine-5-carbonyl chloride used as is in the next step.

後処理

  1. customthe volatiles are removed in vacuo

出典と根拠

ORDレコード
ord-c810a1ac01334986988088ce79433d35
出典データセット
uspto-grants-1985_08
特許番号
US04536512

反応ノート

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