Dimethylamine → 1-Dimethylamino-3-methylamino-2-propanol hydrochloride

HRID 4854ノート

反応式

HRID 4854 の反応式
[CH3:1][NH:2][CH3:3].[CH2:4]([CH:6]1[O:8][CH2:7]1)[Cl:5].[CH3:9][NH2:10]>CO>[ClH:5].[CH3:1][N:2]([CH3:3])[CH2:4][CH:6]([OH:8])[CH2:7][NH:10][CH3:9]

参加物

5

反応物 3

HCID 674DimethylamineHCID 6329MethylamineHCID 7835Epichlorohydrin

生成物 1

HCID 212714991-Dimethylamino-3-methylamino-2-propanol hydrochloride収率 84%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Dimethylamine 22.6 g, 40% solution (0.2 mole) was added dropwise to a solution of 16 ml of epichlorohydrin (0.2 mole) in 100 ml of methanol at 5° C. stirring in an ice bath. After two hours at 5° C. a chilled solution of 86 ml methylamine of 40% solution (1 mole) was poured into the reaction mixture. Stirring was continued in ice bath for one hour and then room temperature overnight. The solvents were evaporated and the clear oil was pumped under vacuum at 75° C. for 1.5 hr to give 28.23 g (~84% yield) of 1-dimethylamino-3-methylamino-2-propanol hydrochloride (I) as the main product.

後処理

  1. stirringStirring
  2. customfor one hour
  3. customroom temperature overnight
  4. customThe solvents were evaporated

出典と根拠

ORDレコード
ord-3f6dd8deeda549f8aafb1ee422df00da
出典データセット
uspto-grants-1988_02
特許番号
US04727152

反応ノート

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