Acetic Acid → 8-Aminodibenzo[b,f]thiepin-3-carboxylic Acid Hydrochloride Salt

反応式

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11][C:10]3[CH:12]=C(C#N)[CH:14]=[CH:15][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:18]=1.[ClH:19].[C:20]([OH:23])(=[O:22])[CH3:21]>>[ClH:19].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11][C:10]3[CH:12]=[C:21]([C:20]([OH:23])=[O:22])[CH:14]=[CH:15][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:18]=1

参加物

反応物 3

HCID 176Acetic Acid

HCID 313Hydrochloric Acid

HCID 131518838-Amino-3-cyanodibenzo[b,f]thiepin

生成物 1

HCID 131518868-Aminodibenzo[b,f]thiepin-3-carboxylic Acid Hydrochloride Salt

実験手順

850 Mg. 8-amino-3-cyanodibenzo[b,f]thiepin is refluxed in a mixture of 20 cc. acetic acid and 20 cc. concentrated hydrochloric acid for 48 hours. The suspended solid is filtered, washed with some acetic acid, dried overnight under vacuum at 70° C. to yield 600 mg. pure compound, m.p. 308°-311° C.