4-Amino-2-methylpyrimidine-5-carbaldehyde → 4-Amino-2-methyl-5-pyrimidinemethanamine

HRID 485482

反応式

HRID 485482 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH:9]=O)=[CH:4][N:3]=1.[NH3:11].CO>O[Mo](O)(=O)=O>[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][NH2:11])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 129047264-Amino-2-methylpyrimidine-5-carbaldehydeHCID 21705897Ammonia methanol

生成物 1

HCID 667624-Amino-2-methyl-5-pyrimidinemethanamine収率 93.5%

試薬・触媒・溶媒 1

HCID 82208Molybdic acid触媒

実験手順

Into an Erlenmeyer's flask of 100 ml, 2.00 g (14.6 millimole) of 2-methyl-4-amino-5-formylpyrimidine, 40 g of 20 wt. % ammonia-methanol solution and 2.0 mg of molybdic acid (H2MoO4.H2O) were added, and the mixture was stirred for 2 hours under room temperature, with the flask being closely stoppered. Following subsequently the same procedure as in Example 1, 2-methyl-4-amino-5-aminomethylpyrimidine was obtained at a yield of 93.5%.

出典と根拠

ORDレコード
ord-c829ba66a22041189243bf237dd00d53
出典データセット
uspto-grants-1985_08
特許番号
US04536577

関連ノート

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