2-Thiophenecarboxaldehyde → Thien-2-yl-hydroxyacetonitrile

HRID 485615

反応式

HRID 485615 の反応式
[CH:1]([C:3]1[S:4][CH:5]=[CH:6][CH:7]=1)=[O:2].[C-:8]#[N:9].[Na+].[O-]S([O-])=O.[Na+]>O>[S:4]1[CH:5]=[CH:6][CH:7]=[C:3]1[CH:1]([OH:2])[C:8]#[N:9]

参加物

5

反応物 3

HCID 73642-ThiophenecarboxaldehydeHCID 8929Sodium CyanideHCID 6399220CID 63992202 回

生成物 1

HCID 11469116Thien-2-yl-hydroxyacetonitrile収率 59.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In this example 25.0 g of 2-formylthiophene was added to a stirred solution containing 10.93 g of sodium cyanide in 37 ml of water at room temperature. 63 ml of aqueous saturated sodium acid sulfite was then slowly added to the stirred mixture. During the addition of the sodium acid sulfite solution, small amounts (about 20 g) of ice were periodically added. The mixture was then stirred for another 15 minutes and extracted with ethyl ether. The ethyl ether extracts were combined, dried over magnesium sulfate and evaporated under vacuum affording 18.4 g of the title compound.

後処理

  1. additionwere periodically added
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under vacuum

出典と根拠

ORDレコード
ord-dc8afed6f1e6470da0a6400d0a8f8159
出典データセット
uspto-grants-1985_08
特許番号
US04537623

関連ノート

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