Ethanol → [1,1'-Biphenyl]-4-amine, 3-nitro-
反応式
[OH-].[K+].[N+:3]([C:6]1[CH:7]=[C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=[CH:10][C:11]=1[NH:12]C(=O)C)([O-:5])=[O:4].C(O)C>O>[N+:3]([C:6]1[CH:7]=[C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=[CH:10][C:11]=1[NH2:12])([O-:5])=[O:4]参加物
5
実験手順
A mixture of potassium hydroxide (2.5 g), 3-nitro-4-acetamido-1,1′-biphenyl (23.5 g), prepared in (A) above, water (6 mL) and ethanol (12 mL) is heated at reflux for one hour. The reaction mixture is cooled to room temperature and then poured into 300 mL of a mixture of water and ice. The solid is collected by filtration and the crude product is recrystallized from methanol (800 mL) to give 14.1 g of the title compound as an orange solid melting at 170-172° C.
後処理
- temperatureis heated
- temperatureat reflux for one hour
- filtrationThe solid is collected by filtration
- customthe crude product is recrystallized from methanol (800 mL)
出典と根拠
- ORDレコード
- ord-36ee64bce7244940aa4c0e7c57eb5c79
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703510B2
反応ノート
読み込み中…