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Acetic Acid → Nandrolone Decanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Decanoic Acid | HCID 2969 | — |
| 反応物 | Nandrolone | HCID 9904 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | Nandrolone Decanoate | HCID 9677 | 88.8% |
反応手順
To a stirred solution of 5,48 g 19-nortestosterone, 4 g decanoic acid, 0.24 g DMAP and 0.19 g pTSA in 35 ml CH2Cl2 is slowly added at 10° C. a solution of 5.6 g DCC in 30 ml CH2Cl2. After 5 h at room temperature 2 ml acetic acid is added. The same work-up procedure as in Example 6 gives 7.6 g of pure 19-nortestosterone decanoate (88% yield) as white crystals from methanol/water. M.P. 35°-36° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04537722 |
| 出典データセット | uspto-grants-1985_08 |
| ORD ID | ord-a747324c27494f3e9207531db3365d42 |
| 出典メモ | uspto-grants-1985_08 |