HCID 13281197、化合物 → 4-(1h-Imidazol-2-ylmethyl)piperidine

HRID 485804ノート

反応式

HRID 485804 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[CH:3][CH:2]=1.O(C)[Na]>CO>[NH:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH2:7][CH:4]1[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 13281197HCID 13281197、化合物HCID 178418582HCID 178418582、化合物

生成物 1

HCID 132811984-(1h-Imidazol-2-ylmethyl)piperidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(4-pyridylmethyl)imidazole (4 g, 0.025M) and platinum oxide (0.4 g) in ethanol (40 ml) and 2NHCl (50 ml) was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness. Crystallization from ethanol gave 4-(1H-imidazol-2-yl-methyl)piperidine as the dihydrochloride salt m.p. 251°-252° C. (5.2 g, 87% yield). The mixture of 2-(4-pyridylmethyl)-imidazole (2.38 g, 10 mM) and NaOCH3 (10 mM) in methanol (20 ml) was stirred for 10 min. and filtered. The filtrate was stripped to dryness and distilled from about 180° to about 200° C./0.3 mmHg to give the free base of 4-(1H-imidazol-2-yl-methyl)piperidine.

後処理

  1. filtrationfiltered
  2. distillationdistilled from about 180° to about 200° C./0.3 mmHg

出典と根拠

ORDレコード
ord-81f2a1beeac944179cae2451e3f52f46
出典データセット
uspto-grants-1985_08
特許番号
US04537969

反応ノート

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