Dichloromethane → Propanoic acid, 2-(4-hydroxyphenoxy)-, ethyl ester

関与物質

反応手順

A mixture of 2.2 g of ethyl 2-(4-formylphenoxy)propionate, 10 ml of methylene chloride and 2.6 g of m-chloroperbenzoic acid, were reacted for 2 hours under reflux, and after an addition of 0.5 g of water, further refluxed for 1 hour. After cooling, the reaction mixture was washed twice with 20 g of a 5% sodium hydrogen carbonate aqueous solution, then with 10 g of a 5% sodium hydrogen sulfite aqueous solution and further with 10 g of water. The mixture was concentrated by distilling off methylene chloride, and then subjected to distillation under reduced pressure, whereby 1.1 g of ethyl 2-(4-hydroxyphenoxy)propionate was obtained as a colorless transparent liquid. The boiling point was from 130° to 140° C./1 mmHg.

情報源と証拠