反応式
C1COCCN1.COC(=O)c1cc(Br)cc2c1nc(C)n2Cc1cccc(C(F)(F)F)c1C>C1COCCO1.CC(=O)O.CC(=O)O.CC(C)(C)[O-].CCCCP(CCCC)CCCC.[K+].[Pd]>COC(=O)c1cc(N2CCOCC2)cc2c1nc(C)n2Cc1cccc(C(F)(F)F)c1C参加物
7
反応物 2
生成物 1
試薬・触媒・溶媒 4
実験手順
methyl 6-bromo-2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-4-carboxylate (441 mg, 1.00 mmol) was taken up with morpholine (435 µl, 5.00 mmol), potassium tert-butoxide (449 mg, 4.00 mmol), tri-n-butylphosphine (49.3 µl, 0.2 mmol) and palladium(II) acetate (22.44 mg, 0.10 mmol) in dioxane (10ml) and heated for 18 hrs at 100°C. The reaction profile showed no required product and only dimer adduct to be present. the reaction was therefore abandoned.
出典と根拠
- ORDレコード
- ord-f93da8755d504800bf04ba573750bf86
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
関連ノート
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