Potassium Carbonate → 3-[(4-Bromophenyl)methyl]-2-butyl-6-(1-hydroxy-1-methylethyl)-4(3H)-quinazolinone

HRID 486034ノート

反応式

HRID 486034 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Br:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][N:14]2[C:13](=[O:15])[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:16]([OH:19])([CH3:18])[CH3:17])[CH:11]=3)[N:6]=[C:5]2[CH2:1][CH2:2][CH2:3][CH3:4])=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 178441842HCID 178441842、化合物

生成物 1

HCID 200793443-[(4-Bromophenyl)methyl]-2-butyl-6-(1-hydroxy-1-methylethyl)-4(3H)-quinazolinone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 1.37 g of 2-butyl-6-(1-hydroxy-1-methylethyl)-4(1H)-quinazolinone in 115 ml of acetone is added 1.58 g of 4-bromobenzyl bromide and 2.18 g of anhydrous potassium carbonate. The resulting suspension is heated to reflux for 16 hours. The reaction mixture is then allowed to cool to room temperature, filtered and the filtrate is concentrated vacuo. The residue is purified by HPLC eluting with ethyl acetate/hexanes (1:3) to provide the desired product.

後処理

  1. temperatureThe resulting suspension is heated
  2. temperatureto reflux for 16 hours
  3. filtrationfiltered
  4. concentrationthe filtrate is concentrated vacuo
  5. customThe residue is purified by HPLC
  6. washeluting with ethyl acetate/hexanes (1:3)

出典と根拠

ORDレコード
ord-cd499bd4835a49149217c6ea7eb975dd
出典データセット
uspto-grants-1994_03
特許番号
US05290780

反応ノート

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