Ethyl Acetate → HCID 53909511、化合物

HRID 486062ノート

反応式

HRID 486062 の反応式
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12]C)[CH:10]=2)[NH:5][C:4]=1[CH2:14][CH2:15][CH3:16])[CH3:2].C(=O)(O)[O-].[Na+].C(OCC)(=O)C>C(O)(=O)C.Br>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[NH:5][C:4]=1[CH2:14][CH2:15][CH3:16])[CH3:2]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 19097339HCID 19097339、化合物

生成物 1

HCID 53909511HCID 53909511、化合物収率 98.8%

試薬・触媒・溶媒 1

HCID 21893785Acetic Acid Mixture with Hydrobromic Acid溶媒

実験手順

3-Ethyl-5-methoxy-2-propyl indole (2.92 g) in 15 ml of hydrogen bromide acetic acid solution was heated at 100° C. for 4 hours. The cooled solution was poured into an aqueous sodium bicarbonate solution (100 ml) and ethyl acetate with stirring. The separated organic layer was washed with water, dried over magnesium sulfate, and concentrated in vacuo. The crude product was chromatographed on silica gel using 30% ethyl acetate in n-hexanes as eluent to yield 3-ethyl-5-hydroxy-2-propyl indole (2.7 g).

後処理

  1. washThe separated organic layer was washed with water
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crude product was chromatographed on silica gel using 30% ethyl acetate in n-hexanes as eluent

出典と根拠

ORDレコード
ord-be1364ea0d074675ac990b494bfe3819
出典データセット
uspto-grants-1994_03
特許番号
US05290788

反応ノート

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